Like saw palmetto or nettle root hair treatment, pygeum is also believed to possess the ability of playing similar roles to synthetic DHT blockers. It is said to inhibit the enzyme 5-alpha reductase, which converts testosterone to the hair loss-causing hormone, DHT. Notwithstanding the lack of concrete scientific backing of any positive effect on pattern baldness, pygeum bark has been used in natural hair treatment that come in forms of pills and capsules.

Pygeum tincture, on the other hand, can be applied topically. While available over the counter, one must still consult a doctor about its dosage and application as there is no standard dosage for thetreatment of hair loss. But the common recommended dosage of either capsules or liquid extracts made from powdered pygeum bark is 50 to 200 mg. It can be consumed at one time in a day or dividedly at different times throughout the day.